Polymorphic forms / hydrates of N- 4- (3-chloro-4-fluoro-phenylamino) -7- (3-morpholin-4-yl-propoxy) -quinazolin-6-yl -acrylamide dihydrochloride, process for their preparation and the use thereof for the manufacture of medicaments with irreversible tyrosine kinase inhibitory activity

摘要

There are described polymorphic forms/hydrates of N-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinaz olin-6-yl]-acrylamide dihydrochloride, processes for their preparation, as well as the use of the same for the preparation of medicaments with irreversible tyrosine kinase inhibiting action.