New colossolactone triterpene compounds, useful as antiinflammatory agents, isolated from mycelium or fruiting bodies of Ganoderma colossum

摘要

Triterpenes (I), designated 'colossolactones' and having a steroidal, oxa-A-homo-steroidal or oxa-A,B-dihomo-steroidal structure, are new. Triterpenes of formula (I), designated 'colossolactones', are new. R1 = dihydroxyalkenyl group or lactone residue of formula (a) or (b); R2 = OH or OC(CO)CH3; R3, R4 = H or OH; X = CH- beta -OH or -O-CO-; Y = CH2CH2 or CH=CH; Z' = C-CH2OC(O)CH3 or C=CH-. (N.B. Some specifically claimed compounds have R2 = H). An Independent claim is included for the preparation of (I).