New 1-(N-substituted amidoalkyl) bicyclic uracil derivatives useful as medicaments for treating ischemia or reperfusion damage, are poly-(ADP-ribose)-synthetase inhibitors

摘要

1-(N-Substituted amidoalkyl) 5,6-fused bicyclic uracil derivatives (I) are new. 1-(N-Substituted amidoalkyl) 5,6-fused bicyclic uracil derivatives of formula (I) and their salts, hydrates, hydrated salts and solvates are new. A = J, CH2-J, J-CH2, CH=CHCH2, CH2CH=CH, CH2CH2-J, J-CH2CH2 or CH2-J-CH2; J = CH2, O or S; E, G = 1-6C alkylene or 3-8C cycloalkylene (optionally substituted by one or more of 1-4C alkoxy, OH or NH2); T = direct bond or CH2; U, V = direct bond or CC (sic); or 6-10C arylene or 5-7 membered heterocyclene (containing 1-3 of O, S and N as heteroatom(s)), both optionally substituted by 1-3 of NO2, CN, halo, R, 3-8C cycloalkyl, OR, CF2, OCHF2, OCF3, OH, NH2, NHR, N(R)2, COOR, SO2NH2, SO2R, SO2NHR, SO2N(R)2 or OCOR; W = direct bond, O, S, COO, OCO or NR4; R4 = H or R; X = O, S or NR5; Y1 = H and Y2 = OH; or Y1 + Y2 = =O, =S or =NR6; R5, R6 = H, R or CH2Ph; R1 = H, R (optionally substituted by one or more halo) or 3-8C cycloalkyl; R2 = H or COOR; R3 = 6-10C aryl or 5-13 membered heterocyclyl (containing 1-4 of O, S and N as heteroatom(s)), both optionally substituted by 1-3 of NO2, CN, halo, R, 3-8C cycloalkyl, OR, CF2, OCHF2, OCF3, OH, =O, NH2, NHR, N(R)2, CH2NHR, CH2N(R)2, COOR, SO2NH2, SO2R, SO2NHR, SO2N(R)2, OCOR or CH2R7; R7 = 5-7 membered heterocycle containing 1-3 of O, S and N as heteroatom(s); and R = 1-6C alkyl. An Independent claim is also included for the preparation of (I).