Tiny structures for the production of paints and spinneret for their preparation

摘要

PROBLEM TO BE SOLVED: To obtain a promoter for osteogenesis, comprising an active ingredient such as a (poly)peptide containing an amino acid sequence comprising Arg- Gly-Asp in the molecule and capable of effectively preventing or treating fracture by its administration to a human body or embedding thereof in a fractured site. ;SOLUTION: This promoter for osteogenesis comprises (A) kistrin, (B) echistatin, (C) a peptide of the formula Gly-Arg-Gly-Asp-Ser, (D) a compound of formula I [R₁ to R₆ are each H, an (OH-substituted)3-10C cycloalkyl, an (OH-substituted)6-12C aryl, etc.; R₇ and R₈ are each OH, a 1-8C alkoxy, a 2-12C alkenyloy, etc.; X is S or O] and (E) at least one of compounds of formula II [R₁₇ is H or a (phenyl-substituted)1-4C alkyl; R₁₆ is a group of the formula N(R₂₀)₂ (R₂₀ is R₁₇), etc.; R₁₈ is H, a 1-4C alkyl, etc.; R₁₉ is an (OH, NH₂, etc., -substituted)1-5C alkyl, etc; Y is a direct bond, NH or O; (a) is 1-3; (b) is 1 or 2; (c) and (d) are each 0 or 1], etc., or a salt thereof.;COPYRIGHT: (C)1997,JPO