Use of the - aspartate - angiotensin i as active substance against cardiac hypertrophy

摘要

91 ABSTRACT2 THE USE OF DES-ASPARTATE-ANGIOTENSIN I AS AN ANTI-CARDIAC3 HYPERTROPHIC AGENT4 The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an5 anti-cardiac hypertrophic agent is described. The compound, given either intravenously or6 orally, prevented the development of experimentally-induced cardiac hypertrophy in rats. Its7 action was dose-dependent and the maximum anti-cardiac hypertrophic effect was obtained8 at a dose of (i) 180 ng/day when given intravenously, and (ii) 285 [err]/day when given orally.This is the replacement sheetDate: 30.12.99