THE USE OF DES-ASPARTATE-ANGIOTENSIN I AS AN ANTI-CARDIAC HYPERTROPHIC AGENT

摘要

The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-cardiac hypertrophic agent is described. The compound, given either intravenously or orally, prevented the development of experimentally-induced cardiac hypertrophy in rats. Its action was dose-dependent and the maximum anti-cardiac hypertrophic effect was obtained at a dose of (i) 180 mg/day when given intravenously, and (ii) 285 mg/day when given orally.