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PROCESS FOR THE SYNTHESIS OF N- (MERCAPTOACYL) -AMINO-ACID DERIVATIVES FROM ALPHA-SUBSTITUTED ACRYLIC ACIDS

机译:由α-取代的丙烯酸合成N-(巯基)-氨基酸衍生物的方法

摘要

The subject of the present invention is a process for the preparation of a compound of formula (I): ## STR1 ## wherein said process comprises a step (B) of performing a Michael addition of a thioacid RS4H on an alpha-substituted acrylic amide derivative. The invention also relates to the enantioselective synthesis of compounds of formula (I) wherein R2 is different from H, in the preferred configuration (S, S): (CF DRAWING IN BOPI) / P
机译:本发明的主题是用于制备式(I)的化合物的方法:其中,所述方法包括步骤(B):在α-取代的丙烯酸上进行硫代酸RS4H的迈克尔加成。酰胺衍生物。本发明还涉及在优选的构型(S,S)中,R 2与H不同的式(I)化合物的对映选择性合成:(CF DRAWING IN BOPI)

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