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New chromeno pyrrolyl pyrimidin-4-one derivatives are antagonists of alpha 2 autoreceptors and 5-HT 2c receptors, suitable for treatment of central nervous system disorders
New chromeno pyrrolyl pyrimidin-4-one derivatives are antagonists of alpha 2 autoreceptors and 5-HT 2c receptors, suitable for treatment of central nervous system disorders
Pyrimidin-4-one derivatives (I), their stereoisomers, and addition salts. Pyrimidin-4-one derivatives (I), their stereoisomers, and addition salts are new. R1, R2, R3, and R4 = H, halogen, 1-6C alkyl, alkoxy or polyhaloalkyl, OH, CN, NO2, or NH2, or two adjacent groups may form an optionally substituted benzene ring or heteroaromatic ring; X = O or CH2; A = 1-6C alkylene; the ring B = an unsaturated nitrogen heterocycle that may be substituted; R5 = 1-6C alkyl.
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机译：嘧啶-4-酮衍生物（I），其立体异构体和加成盐。嘧啶-4-酮衍生物（I），其立体异构体和加成盐是新的。 R1，R2，R3和R4 ＝ H，卤素，1-6C烷基，烷氧基或多卤代烷基，OH，CN，NO2或NH2，或两个相邻基团可形成任选取代的苯环或杂芳族环; X = O或CH 2; A = 1-6C亚烷基;环B ＝可以被取代的不饱和氮杂环; R5 ＝ 1-6C烷基。
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