New material FH1, FH2 and its production manner and the anti-bacterial medicine null which designates that as the

摘要

PROBLEM TO BE SOLVED: To obtain new substances FH-1 and FH-2 having a polyacetylene structure, having an antimicrobial activity, useful as an active ingredient for an antimicrobial agent by culturing Fistulina hepatica, separating and collecting a product from a fruit body of the culture product. ;SOLUTION: The new substance FH-1 is shown by formula I and the new substance FH-2 is shown by formula II. The substances have antimicrobial activity and are useful as active ingredients for antimicrobial agents, etc. The new substances are obtained by mixing Fistulina hepatica with chip of Fagus crenata, a dried malted rice and water, blending the mixture with a solid medium subjected to thermal sterilization treatment, uniformly dispersing the mixture into the solid medium and culturing to obtain a mature fruit body, then chopping the fruit body, extracting the chopped fruit body with acetone, concentrating the acetone solution, adjusting the acetone solution to pH 7.0, extracting the acetone solution with ethyl acetate, collecting the ethyl acetate layer, concentrating the layer to dryness and purifying a crude active fraction by silica gel chromatography and high-performance liquid chromatography.;COPYRIGHT: (C)2000,JPO