Model animal of diurnal variation of blood pressure and urinary sodium excretion

摘要

The present invention provides a model animal of a diurnal variation of blood pressure and a method of using the same. The model animal of the present invention is obtained by lowering the renal function by, for example, renal artery ligation and / or nephrectomy, and can be used as a disease state model of hypertension, for example, non dipper.