6-substituted-4,5-epoxy-6-hydroxy-2-cyclohexene-1-one derivatives and their intermediates

摘要

The present invention relates to the following formulaIn Formula 1, R1 represents a substituted or unsubstituted lower alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted allyl group. A 6-substituted-4,5-epoxy-6-hydroxy-hex-2-hexhexene-1-one derivative and its intermediate intermediate are shown. The compound of the present invention can be a useful preparation intermediate of suxhostin, which is expected to be used as a therapeutic agent for inflammatory systems, immune systems and nervous system diseases, which significantly inhibits neutral sphingomyelinase at low concentrations.