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Use of long-chain N-alkyl derivatives of deoxynojirimycin and the enzyme glucocerebrosidase for the preparation of a medicament for the treatment of disorders of glycolipid abnormal accumulation
Use of long-chain N-alkyl derivatives of deoxynojirimycin and the enzyme glucocerebrosidase for the preparation of a medicament for the treatment of disorders of glycolipid abnormal accumulation
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机译:脱氧野oji霉素的长链N-烷基衍生物和葡糖脑苷脂酶在制备用于治疗糖脂异常蓄积症的药物中的用途
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摘要
A combination drug therapy is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of both a N-alkyl derivative of deoxynojirimycin (DNJ) and a glucocerebrosidase enzyme to alleviate or inhibit the glycolipid storage disease. The alkyl group has from about two to about 20 carbon atoms and preferably is butyl, nonyl or decyl.
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