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Compositions and methods for modulating apoptosis in cells overexpressing a bcl-2 family member protein
Compositions and methods for modulating apoptosis in cells overexpressing a bcl-2 family member protein
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机译:调节过度表达bcl-2家族成员蛋白的细胞凋亡的组合物和方法
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摘要
The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express anti-apoptotic Bcl-2 family member proteins and typically exhibit reduced binding affinity for cytochrome B. Pharmaceutical uses of the agents and compositions include treating apoptosis-associated disease, such as neoplasia and drug resistance, are also disclosed.
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