Use of gabapentin in assays to identify GABAB receptor modulators

摘要

Novel assays utilizing gabapentin to identify agonists, inverse agonists, antagonists, and allosteric modulators of the GABAB receptor, where the functional GABAB receptor results from the co-expression of HG20 and GABABR1a or GABABR1b and formation of heterodimers of HG20 and GABABR1a or GABABR1b subunits, are provided.