Polyaza macrocyclic compounds for forming complexes with metal ions

摘要

A nuclear magnetic resonance contrast composition which comprises a tetraazamacrocyclic compound - paramagnetic lanthanide complex having the formula: CHEM where x is 2, 3 or a combination of p 2(s) and q 3(s) where p + q = 4; R is (CH2)zP(=O)OR1OR2; R1 is H or CH3; R2 is CnH1+2n; z is 1 to 3; r is 2 or 3; M is a paramagnetic lanthanide; and n is 4 to 6. The nuclear magnetic resonance contrast compositions are particularly suitable for liver imaging in a subject.