METHOD FOR EXAMINING EFFECTIVENESS OF GLUCOCORTICOID PREPARATION IN EXAMINEE

摘要

PROBLEM TO BE SOLVED: To provide a method for examining a glucocorticoid preparation in an examinee and to obtain a test reagent.;SOLUTION: In a glucocorticoid receptor (GR), CR which has 643 amino acid residue substituting cystine with arginine, amino acid residues from 722 leucine to 777 lysine substituting with other amino acid residues is found ([C643R variation type GR] and [2314 ins-a variation type GR], respectively). The transcriptive activity of the C643R variation type GR and the 2314 ins-a variation type GR prove to be controlled. The bond affinity of the C643R variation type GR for dexamethasone proves to be low. Consequently, the effectiveness of glucocorticoid is predicted by examining these variations.;COPYRIGHT: (C)2003,JPO