Cell growth control options with inducible high-level mammalian gene expression for promoter-transactivator system

摘要

(57) promoter transactivator system [Abstract] The present invention allows a high level of gene expression controlled cytostatic mammalian cells. Synthesis novel promoters include configuration enhancer elements that allow the expression of basal levels efficiently as an expression achieved by viral promoters very efficient. In addition, the promoter encodes a sequence that binds to the transactivator a controlled activity. Higher levels of expression than the expression by the simple addition of an intermediate such supplements can be obtained from conventional promoters can be achieved.