DISEASE DIAGNOSIS USING GENETIC MUTATION IN PROMOTER REGION OF -GLUTAMYLCYSTEINE SYNTHETASE LIGHT CHAIN GENE

摘要

PROBLEM TO BE SOLVED: To provide a -glutamylcysteine light chain promoter DNA mutant having a mutation at the genetic polymorphism site of the -glutamylcysteine light chain promoter DNA, and to provide a method for evaluating the morbid risk of a coronary artery disease on the basis of the genetic polymorphism.;SOLUTION: This method comprises determining both or one of bases at the -588C/T genetic polymorphism site and the -23G/T genetic polymorphism site in the -glutamylcysteine synthetase light chain promoter gene sequence of a test specimen and then evaluating the morbid risk of the coronary artery disease of the test specimen. And, a DNA is a DNA partial sequence comprising a specific continuous sequence containing both or one of the No.1340 t and the No.1905 t.;COPYRIGHT: (C)2003,JPO