DESMIN GENE HAVING NEW POINT MUTATION CAUSING DILATED CARDIOMYOPATHY

摘要

PPROBLEM TO BE SOLVED: To elucidate the cause of serious sub-line (T) cardiomyopathy isolated from hypertrophic cardiomyopathy hamster (B) and not associated with a macroscopic megalocardia and clarify the pathogenic cause of dilated cardiomyopathy, thereby establishing a method for detecting and identifying the dilated cardiomyopathy and a method for preventing and treating the dilated cardiomyopathy. PSOLUTION: This desmin gene having a point mutation at a site corresponding to the No.571 position of the base sequence in the desimin cDNA translation domain of Syrian hamster. A polypeptide thereof. An oligonucleotide comprising 5 to 250 bases containing the site of the point mutation. An oligonucleotide comprising a complementary sequence thereof. Further, a method for detecting and identifying a site corresponding to the No.571 position of the base sequence in the desmin cDNA translation domain of Syrian hamster. PCOPYRIGHT: (C)2003,JPO