EXOCRINE GLAND TIGHT JUNCTION-CONSTITUTING PROTEIN JEAP FAMILY

摘要

PROBLEM TO BE SOLVED: To obtain a new exocrine gland TJ (tight junction)-constituting protein.;SOLUTION: A mouse cDNA library from gene fragments encoding proteins localizing at cell - cell junctions is screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein (JEAP). GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library is screened to identify JEAP-2. By using prepared antibodies against these proteins, it is revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.;COPYRIGHT: (C)2003,JPO