MOUSE DELETED IN HEMATOPOIETIC FORMING ORGAN TYPE PROSTAGLANDIN D SYNTHETASE GENE AND EXAMINATION METHOD USING THE MOUSE

摘要

PROBLEM TO BE SOLVED: To obtain a mouse deleted in a gene in which H-PGDS gene is knocked out and which causes a congential or reactive disorder in an immune system function, a central nerve function, a circulatory organ function, a reproductive function, etc., by the deletion of the synthase.;SOLUTION: This mouse deleted in a gene is an offspring individual of chimera mouse produced by developing an initial embryo into which a mouse embryonic stem cell having a hematopoietic forming organ type prostaglandin D synthetase gene of genome DNA in which its exon II is subjected to homologous recombination in a variant sequence substituted with neomycin-resistant gene into an individual in a female mouse body and has hematopoietic forming organ type prostaglandin D synthetase gene of genome DNA of productive cell and somatic cell which is substituted with the variant sequence. This method for examining various pharmacodynamic substances using the mouse deleted in the gene is provided.;COPYRIGHT: (C)2003,JPO