METHOD FOR USING PEPTIDE NUCLEIC ACID SELECTIVELY BINDING TO RNA AS ANTISENSE OLIGONUCLEOTIDE, AND METHOD FOR PRODUCING THE PEPTIDE NUCLEIC ACID

摘要

PROBLEM TO BE SOLVED: To provide a method for selectively linking an oligonucleotide analogue to an RNA rather than an DNA.;SOLUTION: This method for linking a peptide nucleic acid represented by formula I [wherein, R¹ is a hydrogen atom or a protective group of an amino acid; R² is a hydroxy group or a protective group of a carboxy group; R³ is a direct bond, a methylene group or an ethylene group; B is a base or a derivative thereof, and may be the same or different; and m is an integer of 1-60] to an RNA having a sequence complementary to the peptide nucleic acid is provided.;COPYRIGHT: (C)2003,JPO