NEW POLYPEPTIDE ESDN, METHOD FOR PRODUCING THE SAME, cDNA ENCODING ESDN, VECTOR COMPRISING THE cDNA, HOST CELL TRANSFORMED BY THE VECTOR, ESDN ANTIBODY, PHARMACEUTICAL COMPOSITION CONTAINING ESDN OR THE ANTIBODY, METHOD FOR ASSAYING ESDN, REAGENT FOR ASSAYING ESDN AND METHOD FOR SCREENING USING ESDN

摘要

PPROBLEM TO BE SOLVED: To provide a new ESDN (endothelial and smooth muscle cell-derived neuropilin-like molecule) protein (polypeptide ESDN) which is expressed in coronary cells and smooth muscle cells and also in the vascular smooth muscle of balloon-damaged arteries or the tunica media of arteria carotis communis, thus useful in treating the restenosis after PTCA in circulatory organ regions or arteriosclerosis. PSOLUTION: The new polpeptide ESDN, a method for producing the same, a cDNA encoding the same, a vector comprising the cDNA, a host cell transformed with the vector, an ESDN antibody, a pharmaceutical composition containing the ESDN or the antibody, a method for assaying the ESDN, a reagent for assaying the ESDN, and a method for screening using the ESDN, are provided, respectively. PCOPYRIGHT: (C)2003,JPO