Antisense inhibiting melanoma invasion and functional analogs thereof

摘要

The present invention relates to an antisense to inhibit melanoma invasion, to an expression vector and to a method for substantially inhibiting tumor cell invasion of an extracellular matrix (ECM) and other invasive processes such as angiogenesis, and particularly plasmin-mediated proteolysis thereof in a patient, by suppression of type I collagenase (MMP-1) expression in the patient.