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Measurement of mutation load using the p53 gene in human cells from paraffin embedded tissues
Measurement of mutation load using the p53 gene in human cells from paraffin embedded tissues
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机译:使用p53基因检测石蜡包埋组织中人细胞中的突变负荷
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摘要
A method for determining mutation load in a somatic cell is determined by mutation analysis of the p53 gene. The p53 gene has been found to be a useful indicator of predisposition to spontaneous mutations or prior carcinogen exposure. Cells that contain mutated p53 tend to accumulate the mutant protein. Thus, DNA from a cell identified by p53 accumulation is amplified and the amplification product further analyzed for mutations in the p53 gene.
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