Synthetic oligonucleotides as inducers of erythroid differentiation

摘要

The invention refers to a synthetic double-stranded oligonucleotide having a length comprised between 10 and 50 bases and a nucleic acid sequence selected from the group consisting of: (a) sequences corresponding to a selected portion of the promoter of human -globin gene; and (b) sequences corresponding to a selected portion of the human genomic region comprised between the -globin gene and the -cluster, for use as an inducer of erythroid differentiation.