A thermostimulation device is disclosed, said device being intended for application to thermographic investigation and allowing sensitivity and specificity in the clinical field of such investigation to be improved, in particular for dermatology, oncology, angiology and capillaroscopy. The finding comprises a probe whose inside is discontinuously supplied with a refrigerating or a heating liquid mixture that comes from a reservoir where it is kept at the temperature that has been set forth previously for the specific test, respectively +5° C. in case of cryostimulation and +40° C. in case of “hot” stimulation. The introduction of the mixture into the probe is adjusted by means of a valve whose opening time is controlled by the operator, so as to determine the passage of a predetermined volume of the mixture immediately before proceeding to thermal stimulation. At the end of thermal stimulation the liquid is sent back from the probe to the reservoir.
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