Control of hunger, satiety, and food intake by modulating expression and activity of cephalic G protein-coupled receptors

摘要

The invention relates to the discovery that two human proteins (G protein-coupled receptors designated GPR12 and GPR3) and their mammalian orthologs, which are known to be expressed in various brain tissues including in the hypothalamus, are involved in regulation of food intake in mammals. The invention includes compositions and methods for modulating expression and activity of these proteins, and methods for identifying such compositions. The invention also includes methods of treating disorders such as obesity, diabetes, and inanity, and methods of modulating body weight.