Inhibition of betaarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia

摘要

The present invention provides a arrestin knockout mouse useful for screening compounds for efficacy in controlling pain, methods of controlling pain in subjects by inhibiting binding of arrestin to phosphorylated opioid receptors, and methods of screening a compound for activity in potentiating opioid receptor agonist activity (e.g., morphine activity) by determining whether or not said compound inhibits arrestin binding to a phosphorylated opioid receptor.