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Substituted 1-aza-2-imino-heterocycles and their use as nicotinic acetylcholin receptors activators
Substituted 1-aza-2-imino-heterocycles and their use as nicotinic acetylcholin receptors activators
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机译:取代的1-氮杂-2-亚氨基杂环化合物及其作为烟碱乙酰胆碱受体激活剂的用途
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摘要
There is provided heterocyclic compounds of the following formula (I): chemistry chemdraw filechemistry mol file;in which, ;A is optionally substituted alkyl group, optionally substituted aryl group or optionally substituted heterocyclic group; ;B1 and B2 are, hydrogen atom, alkyl group or hydroxyl group; or combined together to represent carbonyl group; ;X is oxygen atom, sulfur atom, carbon atom or nitrogen atom; ;dotted line shows either presence or absence of bond; ;n is integer of 1 or 2; and ;the group XY represents optionally substituted alkylene or cyclic alkenylene bond; ;or a pharmaceutically acceptable salt thereof. ;These compounds have good affinity for 42 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.
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