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2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
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机译:2-氨基-3-芳酰基-4,5烷基噻吩:人A1腺苷受体的激动剂变构增强剂
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摘要
The present invention relates to a compound of formula (I): chemistry chemdraw filechemistry mol file;wherein: ;R3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and ;R4 and R5 taken together form a ring having from 5 to 10 carbon atoms. ;Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A1 allosteric enhancer.
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机译:本发明涉及式(I)的化合物: <图像文件=“ US20030078248A1-20030424-C00001.GIF” he =“ 70.0812” id =“ EMI-C00001” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 65.9988“ /> 化学化学绘图文件 ExternalFileRef> 化学mol文件 ExternalFileRef> Chemistry>;其中:R 3 Sub>选自1-萘基,2-萘基和环烷基苯基;和; R 4 Sub>和R 5 Sub>一起形成具有5至10个碳原子的环。另外,本发明提供了一种用于预防或治疗需要增加血管生成的哺乳动物受试者(例如人)中的病理状况或症状的治疗方法,该方法包括向需要这种治疗的哺乳动物施用有效量的上述药物。噻吩选择性腺苷A 1 Sub>变构增强剂。
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