wherein:R3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; andR4 and R5 taken together form a ring having from 5 to 10 carbon atoms.;Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A1 allosteric enhancer."/>
2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
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2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors
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机译：2-氨基-3-芳酰基-4,5烷基噻吩：人A1腺苷受体的激动剂变构增强剂
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摘要
The present invention relates to a compound of formula (I): wherein:R3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; andR4 and R5 taken together form a ring having from 5 to 10 carbon atoms.;Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A1 allosteric enhancer.
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机译：本发明涉及式（I）的化合物：<化学ID =“ CHEM-US-00001”> <图像alt =“嵌入式图像” file =“ US07019027-20060328-C00001.GIF” he =“ 23.20mm” id =“ EMI-C00001” imgContent =“ chem” imgFormat =“ GIF” wi =“ 24.13mm” /> 其中： R 3 选自1-萘基，2-萘基和环烷基苯基;和 R 4 和R 5 一起形成一个碳原子数为5至10的环 ;此外，本发明提供了用于预防或治疗哺乳动物受试者例如人的病理状况或症状的治疗方法，其中增加的血管生成是所希望的，包括对需要这种治疗的哺乳动物给药有效量的上述噻吩选择性腺苷A 1 变构增强剂。
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