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RECEPTOR TYROSINE KINASE WITH A DISCOIDIN-TYPE BINDING DOMAIN
RECEPTOR TYROSINE KINASE WITH A DISCOIDIN-TYPE BINDING DOMAIN
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机译:受体蛋白酪氨酸激酶与DISCOIDIN型结合域
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摘要
A breast carcinoma tyrosine phosphoprotein, DDR (Discoidin Domain Receptor), that defines a novel class of receptor tyrosine kinases is presented. The DDR cDNA predicts a polypeptide C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region suggests an unusual geometry of interaction with ligand or substrates. Discoidin I-type domains may interact with specific cell surface molecules.
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