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Library of novel ''unnatural'' natural products
Library of novel ''unnatural'' natural products
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机译:新颖的“非自然”天然产物图书馆
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摘要
Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical methods. The library includes examples of analogs with one, two and three altered carbon centers of the polyketide products.
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