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Structure of a free regulator of G-protein signaling (RGS4) and methods of identifying agonists and antagonists using same
Structure of a free regulator of G-protein signaling (RGS4) and methods of identifying agonists and antagonists using same
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机译:G蛋白信号传导(RGS4)的自由调节剂的结构以及使用其鉴定激动剂和拮抗剂的方法
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摘要
The present invention provides a solution structure of free RGS4 determined using NMR techniques. The structure includes a G binding site and an allosteric binding site. The structural information provided can be employed to identify, select or design agonists and antagonists of RGS4 activity. The invention includes two dimensional and three dimensional models and representations of the structure of free RGS4 based upon structural coordinates that are provided that are useful in the methods described.
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