Compositions and methods for diagnosis and therapy of malignant mesothelioma

摘要

Disclosed are compositions and methods for the diagnosis and therapy of Wilms tumor antigen-associated cancers, and in particular, malignant pleural mesothelioma. In particular embodiments, the invention provides new, effective methods, compositions and kits for eliciting immune and T cell response to Wilms tumor antigen polypeptide-derived antigenic fragments, and methods for the use of such compositions for diagnosis, detection, treatment, monitoring, and/or prevention of human malignant pleural mesothelioma