Method for predicting drug clearance and individualized dosage

摘要

The present invention provides a blood based method for estimation of drug metabolizing enzyme RNAs in liver. The method comprises the steps of obtaining a blood sample from an individual, isolating one or more types of cells from the sample, preparing total RNA or mRNA from the cells and subjecting the RNA to DNA arrays comprising probes for desired genes to determine the levels of the mRNAs. These levels are then used to estimate corresponding mRNA levels in liver.