HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies

摘要

The invention features a protein which includes a gp120 V1/V2 domain of an HIV-1 strain and not a gp120 V3 domain of an HIV-1 strain, which protein does not substantially bind CD4. The gp120 V1/V2 domain of the protein displays an epitope which is recognized by an antibody which neutralizes at least one HIV-1 primary isolate with a ND₉₀ of less than 100 g/ml.