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Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
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机译:透皮给药雄激素药物氢氧化物释放剂作为渗透促进剂
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摘要
A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered androgenic drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the androgenic drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an androgenic drug are provided as well.
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