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Prevention of diabetes and prolongation of the honeymoon phase of diabetes by administration of GnRH antagonists
Prevention of diabetes and prolongation of the honeymoon phase of diabetes by administration of GnRH antagonists
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机译:通过施用GnRH拮抗剂预防糖尿病和延长糖尿病的蜜月期
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摘要
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Additionally, the present invention provides a method of prolonging the honeymoon phase and decreasing the rate of islet cell infiltration by lymphocytes by administration of a GnRH antagonist. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. Preferred antagonists include Acetyl--2-Naphthyl-D-Ala-D-p-Chloro-Phe--3-Pyridyl-D-Ala-Ser-N-Nicotinoyl-Lys-N-Nicotinoyl-D-Lys-Leu-N-Isopropyl-Lys-Pro-D-Ala-NH2, Nal-Glu, Abarelix, Degarelix, and acetyl-D2Nal-D4CIPhe-D3Pal-Ser-Aph(Ac)-D-Aph(Ac)-Leu-Lys(lpr)-Pro-D-Ala-NH2.
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