PREVENTION OF DIABETES BY ADMINISTRATION OF GNRH ANTAGONISTS

摘要

A method for reducing the incidence or delaying the onset of diabetes indiabetes-susceptible mammals (e.g., mice, rats, humans) is provided whereinthe mammals are treated with a gonadotropin-releasing hormone (GnRH)antagonist. Preferably, the antagonist is administered repeatedly over time bysubcutaneous injection. A useful antagonist is Acetyl-.beta.-[2-Napthyl]-D-Ala-D-p-Chloro-Phe-.beta.[3-Pyridyl]-D-Ala-Ser-N.epsilon.-[Nicotinoyl]-Lys-N.epsilon.[Nicotinoyl]-D-Lys-Leu-N.epsilon.-[Isopropyl]-Lys-Pro-D-Ala-NH2.Other useful antagonists are Nal-Glu, PPI-149 and acryline.