Recombinant segmented negative strand virus containing bicistronic vRNA segment with a duplication of its 3 noncoding flanking sequence, and vaccines and therapeutic compositions containing the same

摘要

The present invention relates to recombinant negative strand RNA molecules which may be used to express heterologous proteins in animal cells and/or to construct recombinant viruses able to express heterologous proteins during their multiplication in host animal cells.