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Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 2 (PS-2) gene
Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 2 (PS-2) gene
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机译:通过检测早老素2(PS-2)基因突变来确定患阿尔茨海默氏病风险的方法
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摘要
The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
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