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iso-CBI and iso-CI analogs of CC-1065 duocarmycins
iso-CBI and iso-CI analogs of CC-1065 duocarmycins
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机译:CC-1065杜卡霉素的iso-CBI和iso-CI类似物
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摘要
A series of bioactive analogs of ()-CC-1065 (1) and the duocarmycins 2 and 3 are synthesized. The bioactive analogs include either iso-CI or iso-CBI (6 and 7) as a DNA alkylation subunit. Conjugated to the DNA alkylating subunits are a variety of DNA binding subunits. The bioactive analogs maintain their DNA selectivity and display enhance reactivity.
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