A process for the preparation of hydrochloride of cis - (1S, 4S) - N - methyl - 4 - (3,4-dichlorophenyl) - 1,2,3,4 - tetrahydro - 1 - naftalenamina

摘要

It reveals a process for the preparation of hydrochloride of cis - (1S, 4S) - N - methyl - 4 - (3,4-dichlorophenyl) - 1 - naftalenamina 1,2,3,4 tetrahydro -,It is decirclorhidrato of sertraline hydrochloride and Intermediate Compound cis - N - methyl - 4 - (3,4-dichlorophenyl) - 1,2,3,4 - tetrahydro - 1 - naftalenamina, comprising 4 - (3, hacerreaccionarDiclorofenil) - 3, 4 -4 - dihydro - 1 - (2H) - naftalenona with methylamine under a reducing atmosphere in the presence of a metu00e1licoreductor Raney Nickel as the catalyst to produce Amine intermediaryTreat the Amine with Hydrogen chloride to produce the correspondienteclorhidrato Amine CIS and transISOLATE and purify the amine hydrochloride to obtain CIS amine hydrochloride Intermediate, and convertirdichoclorhidrato CIS amine hydrochloride in cis - (1S, 4S) - N - methyl - 4 - (3,4 - diclorofenil 1,2,3,4 tetrahydro - (1) - - - naftalenamina, known through the process.