Protein C derivatives and Pharmaceutical compositions made with such Derivatives, recombinant DNA molecules encoding such derivatives; Transforming vectors containing Said derivatives; isolated Nucleic Acids comprising polynucleotides that encode at least 90 d

摘要

Describe and claim New Derivatives of Protein C. are polypeptides that retain the Biological activity of the wild type Human protein C, with half lives in human blood is substantially larger.These polypeptides will require less frequent Dosing and / or a dosage lower than that of the wild type Human protein C in the treatment of vascular occlusive disorders, Hypercoagulable States and diseases that predispose to thrombosis. Specifically, it is derived from the Human protein C comprising SEQ ID NS1.Also, describe and claim the remaining Objects mentioned in the title.