The intermediaries for Small Molecules, their Synthesis,The pharmaceutical compositions containing them and their use for preparing a Medicament for the Treatment or prophylaxis of diseases mediated by inflammatory or immune cells

摘要

The small formula molecule (1) is described,Where can I replace A1, a? notesR3, R4, R5, R7, x, D and Z have the meaning set forth in the descriptive report. These compounds inhibit the interaction of cell binders and can therefore be used to treat or prevent inflammation or diseases transmitted by immune cells. The following compounds are examples of these small molecules: formulas (2) and (3). The intermediate compounds in the above molecular synthesis are also described.The pharmaceutical ingredients containing these molecules, and the use of these molecules to prepare drugs for the treatment or prevention of flammable diseases or diseases treated by immune cells.