Aminomethyl phenyl cyclohexanone Derivatives, Process for their preparation, the use of Derivatives of aminomethyl phenyl cyclohexanone for the preparation of medicaments and medicaments containing aminomethyl phenyl cyclohexanone derivatives

摘要

1. Amino phenyl cyclohexane derivatives from the ordinary formula (1) or (2), wherein R1 and R2 independently represent R5 or Yr5 within the selected time, and a group of substances composed of c1-10-tar, c2-10-aldehydes or c2-10-tar, separated or non separated daughters, Monkey or PBDEs not replaced or fused and selected to include h, F, Cl, Br, I, CN, NO2, c1-8-tar, c2-8-alquinio or c2-8-tar, segregator or unseparated, unreplaced or unreplaced or unsaturated or unsaturated c3-7-cyclo The carbon atoms in the cycle are replaced by s, O NR6, R7, OC (o) R7.OC (O) OR7, OC (S) R7, C (O) R7, C (O) OR7, C (S) R7, C (S) OR7, SR7, S (O) R7 or S (O) 2R7, R7 H, C1-18-alkyl, C2-18-alkenyl or C2-18-alkynyl, branched or unbranched, unsubstituted or mono or polysubstituted; C3-7-cycloalkyl, saturated or unsaturated, unsubstituted or mono or polysubstituted, or a corresponding heterocycle, in which a carbon atom in the cycle is substituted by S, O or NR8, saturated or unsaturated, unsubstituted or monoalkylaryl or polysubstituted; aryl or heteroaryl, unsubstituted or mono or polysubstituted; or NR9R10, C (O) NR9R10 or S (O) 2NR9R10, R9 and R10 being independently from each other between H, C1-18-alkyl, C2-18-alkenyl or C2-18-alkynyl,Unreplaced or unreplaced bunches, or unreplaced bunches or polymers, c3-7-cycloquilo, saturated or unsaturated, or unsaturated or unsaturated, or unreplaced monkeys or polymers, or related heterocycles in which the carbon atoms in the cycle are replaced by s or nr11, leased saturated or unsaturated, or unsaturated, unreplaced or single displaced, Arilo or heteromorphic arilo without displacement, or monkey or PVC without displacement, or R9 and R10 together, represent c3-7-cyclo, saturated or unsaturated, or unsaturated or unsaturated, or polymer without displacement, or corresponding heteromorphic cycle, in which carbon atoms are replaced by s or nr12, wherein r12h, c1-10-tar, c2-10-alquenilo or c2-10-tar, Branch or unbranchedUnreplaced monkeys or fusion; or R1 and R2 as a whole, forming - CH = ch - CH = ch -.Whether it is a single cell system or a multicellular system, X is selected from h, F, Cl, Br, I, CF3, O-S (o) 2-c6h4-pch3, or13 or OC (o) R13 to represent R13, h, c1-10-tar, c2-10-alquenio or c2-10-tar, branched or nonbranched, unreplaced or single or multi replaced, c3-7-cyclo-cyclo-cyclo-quilo, saturated unsaturated / unsaturated, unreplaced O polybrominated diphenyl ether or a related heterocycle in which a carbon atom is replaced by N, s, u, rented saturated or unsaturated, unsubstituted, unsubstituted, unsubstituted monkey or polybrominated diphenyl ether, arilo or isomerized, unsubstituted or unsubstituted monkey or polybrominated diphenyl ether;Or when the compound lacks the second formula (2) of X, carbon atoms A and B or carbon atoms B and C form a double connection; while R3 and R4 are selected independently of the group consisting of H, c1-10-tar, c2-10-alquinio or c2-10-tar, branched or unbranched, a. C3-7-cycloquilo, saturated or unsaturated, saturated or unsaturated, unsaturated or unsaturated, unsaturated or unsaturated, or unreplaced monkey or polybrominated diphenyl ether, or the carbon atom in the corresponding cycle is replaced by N, s or O; saturated or unsaturated or unsaturated, unreplaced rental or monkey or polybrominated substitute; a. Arilo or heterosexual without replacement or replacement;Or R3 and R4 combine to form c3-7-cycloquilo, saturated or unsaturated, unsubstituted, or monkey or polymer, or related heterocycle, in which a carbon atom is replaced by s, or nr14, its preparation procedure, the use of drugs and derivatives containing aminobenzene phenyl cyclohexane derivatives Noting that aminobenzene phenyl cyclohexane is used for analgesics or for the treatment of flammable and allergic reactions, depression, substance abuse and / or alcohol, gastritis, cardiovascular disease, respiratory disease, cough, psychosis and / or epilepsy,Especially urinary incontinence, Prut and / or diarrhea.