To treat desacomodamiento fundico Compounds, Pharmaceutical compositions containing Same, Process for preparing such compositions and Process for preparing such compounds

摘要

Formula compound (1),In the chemical isomerization isomer, N-oxide is an addictive salt or a salt of tetrabromodiphenyl ether acceptable for the same drug, where - A1 = A2-A3 = A4 - is a bivalent formula - n = CH-CH = ch -.-CH=N-CH=CH---CH=CH-N=CH---CH=CH-CH=N---N=N-CH=CH---N=CH-N=CH---N=CH-CH=N---CH=N-N=CH---CH = N-CH = N-,or ûCH = CH-N = N-;-Z1-z2 is a hybrid compounding laser CH (R4) - CH2-Y1-CH (R4) -O-,-Y1-CH (R4) -CH2-O-,-Y1-CH (R4) -CH2-S-,-Y1-CH (R4) -CH2-NH-,-Y1-CH (R4) -CH2-CH2-,-Y1-CH (R4) -CH2-CH2-CH2-,-Y1-CH (R4) 3DCH--Y1-CH (R4) 3DCH-CH2--Y1-CH (R4) -CH = CH-,-Y1-CH (R4) 3DCH-CH2-CH2-Or a ch2-ch (R4)wherein, when possible, optionally one or two hydrogen atoms of the same or different carbon or nitrogen atom may be replaced by hydroxyl, C1-4alkyloxyC1-4alkyl, C1-4alkylcarbonyl or C1-6 alkyl optionally substituted with halogen, hydroxyl, C3-6 cycloalkyl or phenyl; Y1 is oxygen or sulfur; Alk1 is C1-4alkylcarbonyl, C1-4alkylcarbonyl, C1-4C1-4alkylcarbonyl, C1-6alkylcarbonyl or optionally substituted with hydroxy, halogen, amino, C1-4alkyl, C1-4 hydroxycarbonyl, C1-alkyloxycarbonyl -4, aminocarbonyl, mono- or di (C1-4alkyl) aminocarbonyl, C1-4alkyloxyC1-4alkyl,C1-4alkylcarbonyloxy, C1-4alkylcarbonyloxyC1-4alkylcarbonyloxy, C1-4alkyloxyimino, phenylC1-4alkylamino, C1-4alkyloxycarbonylC4-6alkenyl, cyano C1-6 alkenyl or C1-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; R1, R2 and R3 are each independently selected from hydrogen, C1-6 alkyl, C3-6 alkenyl, C1-6 hydroxycarbonyl, trihalomethyl, trihalomethoxy, halogen, hydroxy, cyano, nitro, amino, C1-6 alkylcarbonylamino, C1- 6alkyloxycarbonyl, C1-4alkyloxycarbonyloxy, aminocarbonyl, monoû or di (C1-6alkyl) aminocarbonyl, C1-6 aminoalkyl mono- or di (C1-6alkyl) aminoC1-6alkyl,C1-4alkylcarbonyloxyC1-4alkyloxycarbonyloxy or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; R4 is hydrogen, hydroxycarbonyl, phenyl, aminicarbonyl, mono- or di (C1-4alkyl) aminocarbonyl, C1-4alkyloxyC1-4alkyl, C1-4alkyloxycarbonyl, N-pyrrolidinecarbonyl, N-piperidinylcarbonyl, N-homopiperidinylcarbonyl, C1-4alkylcarbonyl, C1-4alkylcarbonyl, C1-4alkylcarbonyl -4C1-4alkyloxycarbonylC1-4alkyl, C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy or C1-6alkyl optionally substituted with hydroxyl, cyano, amino, phenyl, monoû or di (C1-4alkyl) amino or mono- or di (C1-4alkyl) aminocarbonyl; -A- is a bivalent radical of formulas (2) to (8) in which m is 0 or 1;Alk2 is a bivalent radical selected from C1-4alkylcarbonylC1-4alkyl; phenyl; C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; C3-6cycloalkandiyl optionally substituted with one or more halogens, hydroxyl, hydroxycarbonyl, hydroxyC1-4alkyl, C1-4alkyloxy, C1-4alkyloxyC1-4alkyl, C1-4alkyloxycarbonyl, C1-4alkylcarbonyloxyC1-4alkyloxycarbonyloxy, C3-6alkylcarbonyloxycarbonylcarbonyloxycarbonylcarbonyloxycarbonylcarbonylcarbonyloxycarbonyl or C1-6 alkyl optionally substituted with one or more hydroxyls, halogen, amino, hydroxycarbonyl, hydroxyC1-4alkyl, C1-4 alkyloxy, C1-4alkyloxyC1-4alkyl, C1-4alkyloxycarbonyl, C1-4alkylcarbonyloxyC1-4alkyloxycarbonyloxy, C3- cycloalkyl 6,aminocarbonyl, mono- or di (C1-4alkyl) aminocarbonyl or C1-6 alkyl in which C1-6 alkyl together with the carbon atom to which it is attached can form a C3-6 cycloalkyl; R6 is hydrogen, C1-4 alkyl, halogen, hydroxyl, C1-4 hydroxyalkyl, C1-4 alkyloxy C1-4 aminoalkyl, C1-4 alkyloxycarbonyl, C1-4alkylcarbonyloxyC1-4alkyloxycarbonyl, amino, hydroxycarbonyl, aminocarbonyl, mono - or di (C1-4alkyl) aminocarbonyl or C3-6cycloalkylcarbonyloxyC1-4alkyloxycarbonyloxy; R5 is a radical of formulas (9) to (13) in which n is 1 or 2, p1 is 0 and p2 is 1 or 2; or p1 is 1 or 2 and p2 is 0; X is oxygen, sulfur, NR9 or CHNO2; Y2 is oxygen or sulfur;R7 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, phenyl or phenylmethyl; R 8 is C 1-6 alkyl, C 3-6 cycloalkyl, phenyl or phenylmethyl; R9 is cyano, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyloxycarbonyl or aminocarbonyl; R10 is hydrogen or C1-6 alkyl; or R9 and R10 taken together with the nitrogen atom to which they are attached can form a pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl or morpholinyl group, optionally substituted with C1-4 alkyl or C1-4 alkyloxy; and Q is a bivalent radical of formulas: -CH2-CH2-,-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH=CH---CH2-CO...-CO-CH2...- (CH2) 2-CO-,-CO- (CH2) 2-,-CO-CH2-CO-CH2-CO-CH2-,In this case, one or two hydrogen atoms of the same or different carbon atoms can be replaced by C1-4 tar, hydroxy or phenyl, or q is a bivalent formula (14) or (15). These compounds are used to repair the changed furnaces The pharmaceutical compounds containing these compounds, the process of preparing these compounds and the process of preparing these compounds are also disclosed.