Method for inhibiting one or more activities of protein kinase, composed of 2 - 5 - One pirazolin - protein kinase inhibitor and Pharmaceutical composition containing same

摘要

A method to inhibit one or more activities of kinase Protein comprising administering a compound of pirazolin - 2 - 5 - One represented by the formula (1) and physiologically acceptable Salts and Biologically Active Metabolites of the same, where r is selected from the group of a group Or replaced without replacing group consisting of: aliphatic, aromatic, a cycloalkyl Group (C3 - 6)A Group aralquilo Heterocyclic Group, an alkyl group, a cicloalquil (C3 - 6) and a group of heterociclil alkyl; r1 is Hydrogen or a-z; R2 is Hydrogen or replaced without replacing or selected from the group consisting of: Lower alkyl group, an Aromatic Group, a cycloalkyl Group (C3 - 6) Group, a Heterocyclic Group, an alkyl group aralquilo, a cicloalquil (C3 - 6)And a Group heterociclil alkyl; where a and Z are as described in the report.A compound of pirazolin - 2 - 5 - One represented by the formula (2) and physiologically acceptable salts thereof, wherein R is selected from the group consisting of substituted or non substituted indole: 1,2,3 - triazole, imidazole, benzimidazole, 1,2,4-triazole, also tetrahidroindol benzoindol azaindol -,,, Indazol, quinoline, pyridine, pyrazine, pyrimidine, benzene, pyrazole, pyrrole,Oxazole and thiazole; r1 is Hydrogen or - Z -, where a and Z are as described in the report. A Pharmaceutical composition comprising the compound described and a pharmaceutically acceptable diluent or vehicle.